Research in the Winkle Lab focuses on the interactions of small molecules such as antiparasitic agents, carcinogens and anticancer drugs, with DNA and on the interactions of proteins with DNA. We are interested in how these species alter the structure and functioning of DNA and in how altering the structure of the bound molecule affects such alterations.
- Jessie Limonta (Stephen Winkle) “Locating High Affinity Binding Sites of the Carcinogen 4-Nitro-Quinoline-1-Oxide on PhiX 174 DNA”
- Juan Medina (Stephen Winkle) “The Binding of Carcinogen 4-Nitroquinoline-1-Oxide and Acitnomycin D to PhiX174 DNA”
- Tayliz Rodriguez (Stephen Winkle) “Effects of Heterocyclic Diamidine Antiparasitic Agent Binding to DNA on Restriction Enzyme Kinetics”
- Elizabeth Tinoco (Stephen Winkle) “Examining the Binding of 4-Nitroquinolise-1-Oxide to PhiX174 DNA Using Mung Bean Nuclease and Topoisomerase I Assays”
- Javier Valdes (Stephen Winkle) “Selectivity, Cooperativity and Competition in the Binding of Heterocyclic Diamidines to DNA”