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The Proceedings of the 15th Constructal Law Conference (CLC2025) bring together interdisciplinary contributions organized around the central theme Evolution, Design, Nature, and Society. The collected works examine how flow systems evolve to provide greater access under the Constructal Law, spanning fundamental theory, modeling, experiments, and applications. Topics include energy and heat transfer systems, fluid–structure interaction, biological and social flow architectures, artificial intelligence, and engineered systems. A unifying perspective across the proceedings is the role of evolving configuration—rather than material quantity—in governing performance and functionality. Together, these contributions demonstrate the Constructal Law as a predictive, physics-based framework for understanding the evolution of design across natural, technological, and societal systems.

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